P2Y2 Receptor-mediated Lymphotoxin-α (LTA) Secretion Regulates Intercellular Cell Adhesion Molecule (ICAM)-1 Expression in Vascular Smooth Muscle Cells
نویسندگان
چکیده
Capsule Background: Lymphotoxin-alpha (LTA) is involved in the pathogenesis of atherosclerosis. Results: The P2Y2 nucleotide receptor (P2Y2R) recruits filamin A to activate Rho signaling upstream of LTA secretion leading to intercellular cell adhesion molecule-1 expression. Conclusion: P2Y2R regulates LTA gene activation and secretion in vascular smooth muscle cells. Significance: This suggests that P2Y2R is an important regulator of vascular inflammation.
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